No. The risks outweigh the benefits. While the concept of carrying AutoCAD Mechanical on a keychain is appealing, the "F5100 Portable ENG" version is:
Newer AutoCAD versions require modern operating systems (Windows 10/11 64-bit). The "F5100" moniker often surrounds older, lightweight builds (e.g., based on AutoCAD 2015-2018) that run on aging hardware (Windows 7/8, limited RAM) where standard installation fails.
Why would a professional risk using a non-standard portable version of a 5+ GB software suite? The reasons usually fall into three categories: