Microsoft has changed how this pack is distributed over the years. Here are the definitive methods for 2024.
Overall Rating: ⭐⭐⭐⭐☆ (4/5) – Essential for legacy maintenance, but obsolete for new development. microsoft .net framework 4 multi targeting pack
Generally, no. The targeting pack is small (tens of MB) and non-intrusive. However, if you are absolutely certain you will never touch .NET 4.0 code again: Microsoft has changed how this pack is distributed