Resident Evil 6 Fatal Error Failed Open File Guide
A broken config.ini or corrupted save may trigger the error.
When Resident Evil 6 says it "Failed to open a file," it means the game engine attempted to access a specific asset (a texture, sound, cutscene video, or character model) stored in the game directory, but either: resident evil 6 fatal error failed open file
If all else fails, it’s time for drastic measures. A broken config
If you can see the game's splash screen for a second before the error, your existing configuration file might be corrupted. Restart the game