Here is the critical issue. If you install SKSE 16342, your game will crash on launch if Steam updates your SkyrimSE.exe to version 1.6.640 or higher.
You must lock your game version. This usually involves:
Probably not. Here is the honest recommendation: skse 16342
Version 16342 is the middle child of Skyrim modding. It works well, but it lacks the total mod count of 1.5.97 and lacks the new features of 1.6.1170.
Cause: You have a mod (e.g., SkyUI) that requires a newer SKSE than 1.6.342.
Fix: Downgrade your mods. Specifically, install SkyUI 5.2 SE (not the AE versions). Check each DLL mod’s requirements page for "Compatible with 1.6.342." Here is the critical issue
❌ Version-sensitive – updating Skyrim breaks SKSE until updated
❌ No longer the current standard (most new mods target 1.6.640 or 1.6.1170)
❌ Requires manual updating of SKSE-dependent mods when you change game version
In late 2024 and into 2025, the modding scene has largely consolidated around SKSE 2.2.3 (for runtime 1.6.640). Most major mod authors have finally updated their work. Version 16342 is the middle child of Skyrim modding
However, SKSE 16342 will never become completely obsolete for three reasons:
If you are building a new mod list today, you should likely use SKSE 1.6.640. But if you are maintaining an existing 500+ mod load order that has worked for two years, do not upgrade. Stick with SKSE 16342.